L-α-dipeptides (dipeptides) haisati yadzidzwa zvinenge zvakawanda zvine mapuroteni uye amino acids.Tsvagiridzo yekutanga yakaitwa paL-aspartyl-L-phenylalanine methylester (aspartame) uye Ala-Gln (Lalanyl-L-glutamine) nekuti anoshandiswa mune zvakakurumbira zvigadzirwa zvekutengesa.Pamusoro peichi chokwadi, chimwe chikonzero nei dipeptides mazhinji asina kunyatsodzidza imhaka yekuti kugadzirwa kwedipeptide kunoshaya maitiro ekugadzira anoshanda, kunyangwe akati wandei makemikari uye chemoenzymatic nzira dzakataurwa.
Carnosine - muenzaniso we dipeptide
Kusvika nguva pfupi yadarika, nzira nyowani dzakagadzirwa dzedipeptide synthesis iyo dipeptides inogadzirwa kuburikidza nekuvirisa maitiro.Mamwe dipeptide ane akasiyana physiological hunyanzvi, achivabvumira kuti vakurumidze kunyorera dipeptide munzvimbo dzakasiyana dzekutsvaga kwesainzi.L-α-dipeptides inoumbwa neyakaomesesa peptide bond yeamino acids maviri, asi haiwanikwe nyore kunyanya nekuda kweiyo exiguity yekudhura-inoshanda maitiro ekugadzira.Dipeptides, zvisinei, ine mabasa anofadza zvikuru, uye ruzivo rwesayenzi rwakavapoteredza rwuri kuwedzera.Izvi zvinosiya vaongorori vazhinji vaine mhosva yekuvandudza maitiro anoshanda uye anodhura ekugadzira dipeptide.Kana iyi ndima yakanyatso kudzidzwa, zvinotarisirwa kuti tinogona kudzidza zvakawanda nezve kukosha kwepeptides.
Dipeptides ine maviri akakosha mabasa, ayo anoti:
1. Kubva kune amino acids
2. Iyo dipeptide pachayo
Sezvinobva kumaamino acids, dipeptides, pamwe nemaamino acids ayo ane akasiyana physiochemical properties, asi anowanzo kugovana zvakafanana zvemuviri mhedzisiro.Izvi zvinodaro nekuti dipeptides akaderedzwa kuita akaparadzana amino acids mune zvipenyu zvipenyu, izvo zvine akasiyana physicochemical properties.Semuenzaniso, L-glutamine (Gln) inopisa-labile, nepo Ala-Gin (L-alanyl-L-glutamine) inoshivirira kupisa.
Kemikari synthesis yedipeptides inoitika seinotevera:
1. Mapoka ese anoshanda dipeptide anodzivirirwa (kunze kweaya anobatanidzwa mukugadzira peptide bond yeamino acids).
2. Iyo yakachengetedzwa amino acid yeboka remahara carboxyl rinoitwa.
3. Iyo amino acid yakagadziriswa inopindirana neimwe yakachengetedzwa amino acid.
4. Mapoka anodzivirira ari mukati medipeptide anobviswa.
Nguva yekutumira: Kubvumbi-19-2021
